Apoptosis-Inducing Factor Modulates Mitochondrial Oxidant Stress in Acetaminophen Hepatotoxicity

Acetaminophen (APAP) overdose causes liver injury in humans and mice. DNA fragmentation is a hallmark of APAP-induced cell death, and nuclear translocation of apoptosis-inducing factor (AIF) correlates with DNA fragmentation after APAP overdose. To test the hypothesis that AIF may be a critical medi...

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Main Authors: Bajt, Mary Lynn, Ramachandran, Anup, Yan, Hui-Min, Lebofsky, Margitta, Farhood, Anwar, Lemasters, John J., Jaeschke, Hartmut
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2011
Ábhair:
Systems Toxicology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3155087/
https://ncbi.nlm.nih.gov/pubmed/21572097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfr116
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