Removal of Acetaminophen-Protein Adducts by Autophagy Protects Against Acetaminophen-Induced Liver Injury in Mice

BACKGROUND & AIMS: Acetaminophen (APAP)-induced liver injury is the most frequent cause of acute liver failure in the US and many other countries. Metabolism of APAP results in formation of APAP protein adducts (APAP-AD) in hepatocytes and triggers mitochondrial dysfunction and necrosis. However...

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Udgivet i:J Hepatol
Main Authors: Ni, Hong-Min, McGill, Mitchell R., Chao, Xiaojuan, Du, Kuo, Williams, Jessica A., Xie, Yuchao, Jaeschke, Hartmut, Ding, Wen-Xing
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955750/
https://ncbi.nlm.nih.gov/pubmed/27151180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2016.04.025
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