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The Receptor Interacting Protein Kinase 3 is a Critical Early Mediator of Acetaminophen-induced Hepatocyte Necrosis in Mice
Acetaminophen (APAP) overdose is a major cause of hepatotoxicity and acute liver failure in the US, but the pathophysiology is incompletely understood. Despite evidence for apoptotic signaling, hepatic cell death after APAP is generally considered necrotic in mice and in humans. Recent findings sugg...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3791212/ https://ncbi.nlm.nih.gov/pubmed/23744808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26547 |
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