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The Receptor Interacting Protein Kinase 3 is a Critical Early Mediator of Acetaminophen-induced Hepatocyte Necrosis in Mice

Acetaminophen (APAP) overdose is a major cause of hepatotoxicity and acute liver failure in the US, but the pathophysiology is incompletely understood. Despite evidence for apoptotic signaling, hepatic cell death after APAP is generally considered necrotic in mice and in humans. Recent findings sugg...

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Hlavní autoři: Ramachandran, Anup, McGill, Mitchell R., Xie, Yuchao, Ni, Hong-Min, Ding, Wen-Xing, Jaeschke, Hartmut
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791212/
https://ncbi.nlm.nih.gov/pubmed/23744808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26547
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