Spatial intra-tumour heterogeneity in acquired resistance to targeted therapy complicates the use of PDX models for co-clinical cancer studies

od Wellbrock, Claudia
Izdano u EMBO Mol Med (2015)

Elevated expression of MITF counteracts B-RAF–stimulated melanocyte and melanoma cell proliferation

od Wellbrock, Claudia, Marais, Richard
Izdano 2005

Microphthalmia‐associated transcription factor in melanoma development and MAP‐kinase pathway targeted therapy

od Wellbrock, Claudia, Arozarena, Imanol
Izdano u Pigment Cell Melanoma Res (2015)

The Complexity of the ERK/MAP-Kinase Pathway and the Treatment of Melanoma Skin Cancer

od Wellbrock, Claudia, Arozarena, Imanol
Izdano u Front Cell Dev Biol (2016)

Overcoming resistance to BRAF inhibitors

od Arozarena, Imanol, Wellbrock, Claudia
Izdano u Ann Transl Med (2017)

Molecular Pathways: Maintaining MAPK inhibitor sensitivity by targeting non-mutational tolerance

od Smith, Michael P, Wellbrock, Claudia
Izdano u Clin Cancer Res (2016)

Targeting MITF in the tolerance-phase

od Arozarena, Imanol, Smith, Michael P., Wellbrock, Claudia
Izdano u Oncotarget (2016)

Combination of MEK and SRC inhibition suppresses melanoma cell growth and invasion

od Ferguson, Jennifer, Arozarena, Imanol, Ehrhardt, Michael, Wellbrock, Claudia
Izdano 2012

Differentiation of THP1 Cells into Macrophages for Transwell Co-culture Assay with Melanoma Cells

od Smith, Michael P, Young, Helen, Hurlstone, Adam, Wellbrock, Claudia
Izdano u Bio Protoc (2015)

Glucose availability controls ATF4-mediated MITF suppression to drive melanoma cell growth

od Ferguson, Jennifer, Smith, Michael, Zudaire, Isabel, Wellbrock, Claudia, Arozarena, Imanol
Izdano u Oncotarget (2017)

Oncogenic BRAF Regulates Melanoma Proliferation through the Lineage Specific Factor MITF

od Wellbrock, Claudia, Rana, Sareena, Paterson, Hugh, Pickersgill, Helen, Brummelkamp, Thijn, Marais, Richard
Izdano 2008

In melanoma, beta-catenin acts as suppressor of invasion through a cell-type specific mechanism

od Arozarena, Imanol, Bischof, Helen, Gilby, Daniel, Belloni, Benedetta, Dummer, Reinhard, Wellbrock, Claudia
Izdano 2011

Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells

od Arozarena, Imanol, Goicoechea, Ibai, Erice, Oihane, Ferguson, Jennnifer, Margison, Geoffrey P, Wellbrock, Claudia
Izdano 2014

The Brn-2 Transcription Factor Links Activated BRAF to Melanoma Proliferation

od Goodall, Jane, Wellbrock, Claudia, Dexter, Timothy J., Roberts, Karen, Marais, Richard, Goding, Colin R.
Izdano 2004

Heterogeneous Tumor Subpopulations Cooperate to Drive Invasion

od Chapman, Anna, Fernandez del Ama, Laura, Ferguson, Jennifer, Kamarashev, Jivko, Wellbrock, Claudia, Hurlstone, Adam
Izdano u Cell Rep (2014)

Collagen abundance controls melanoma phenotypes through lineage-specific microenvironment sensing

od Miskolczi, Zsofia, Smith, Michael P., Rowling, Emily J., Ferguson, Jennifer, Barriuso, Jorge, Wellbrock, Claudia
Izdano u Oncogene (2018)

Apoptosis Suppression by Raf-1 and MEK1 Requires MEK- and Phosphatidylinositol 3-Kinase-Dependent Signals

od von Gise, Alexander, Lorenz, Petra, Wellbrock, Claudia, Hemmings, Brian, Berberich-Siebelt, Friederike, Rapp, Ulf R., Troppmair, Jakob
Izdano 2001

Effect of SMURF2 Targeting on Susceptibility to MEK Inhibitors in Melanoma

od Smith, Michael P., Ferguson, Jennifer, Arozarena, Imanol, Hayward, Robert, Marais, Richard, Chapman, Anna, Hurlstone, Adam, Wellbrock, Claudia
Izdano 2013

The melanocortin receptor agonist NDP-MSH impairs the allostimulatory function of dendritic cells

od Rennalls, La’Verne P, Seidl, Thomas, Larkin, James M G, Wellbrock, Claudia, Gore, Martin E, Eisen, Tim, Bruno, Ludovica
Izdano 2010

A PAX3/BRN2 rheostat controls the dynamics of BRAF mediated MITF regulation in MITF(high)/AXL(low) melanoma

od Smith, Michael P., Rana, Sareena, Ferguson, Jennifer, Rowling, Emily J., Flaherty, Keith T., Wargo, Jennifer A., Marais, Richard, Wellbrock, Claudia
Izdano u Pigment Cell Melanoma Res (2018)