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Elevated expression of MITF counteracts B-RAF–stimulated melanocyte and melanoma cell proliferation

The protein kinase B-RAF is a human oncogene that is mutated in ∼70% of human melanomas and transforms mouse melanocytes. Microphthalmia-associated transcription factor (MITF) is an important melanocyte differentiation and survival factor, but its role in melanoma is unclear. In this study, we show...

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Bibliografische gegevens
Hoofdauteurs: Wellbrock, Claudia, Marais, Richard
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2005
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171350/
https://ncbi.nlm.nih.gov/pubmed/16129781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200505059
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