Spatial intra-tumour heterogeneity in acquired resistance to targeted therapy complicates the use of PDX models for co-clinical cancer studies

Por Wellbrock, Claudia
Publicado no EMBO Mol Med (2015)

Elevated expression of MITF counteracts B-RAF–stimulated melanocyte and melanoma cell proliferation

Por Wellbrock, Claudia, Marais, Richard
Publicado em 2005

Microphthalmia‐associated transcription factor in melanoma development and MAP‐kinase pathway targeted therapy

Por Wellbrock, Claudia, Arozarena, Imanol
Publicado no Pigment Cell Melanoma Res (2015)

The Complexity of the ERK/MAP-Kinase Pathway and the Treatment of Melanoma Skin Cancer

Por Wellbrock, Claudia, Arozarena, Imanol
Publicado no Front Cell Dev Biol (2016)

Overcoming resistance to BRAF inhibitors

Por Arozarena, Imanol, Wellbrock, Claudia
Publicado no Ann Transl Med (2017)

Molecular Pathways: Maintaining MAPK inhibitor sensitivity by targeting non-mutational tolerance

Por Smith, Michael P, Wellbrock, Claudia
Publicado no Clin Cancer Res (2016)

Targeting MITF in the tolerance-phase

Por Arozarena, Imanol, Smith, Michael P., Wellbrock, Claudia
Publicado no Oncotarget (2016)

Combination of MEK and SRC inhibition suppresses melanoma cell growth and invasion

Por Ferguson, Jennifer, Arozarena, Imanol, Ehrhardt, Michael, Wellbrock, Claudia
Publicado em 2012

Differentiation of THP1 Cells into Macrophages for Transwell Co-culture Assay with Melanoma Cells

Por Smith, Michael P, Young, Helen, Hurlstone, Adam, Wellbrock, Claudia
Publicado no Bio Protoc (2015)

Glucose availability controls ATF4-mediated MITF suppression to drive melanoma cell growth

Por Ferguson, Jennifer, Smith, Michael, Zudaire, Isabel, Wellbrock, Claudia, Arozarena, Imanol
Publicado no Oncotarget (2017)

Oncogenic BRAF Regulates Melanoma Proliferation through the Lineage Specific Factor MITF

Por Wellbrock, Claudia, Rana, Sareena, Paterson, Hugh, Pickersgill, Helen, Brummelkamp, Thijn, Marais, Richard
Publicado em 2008

In melanoma, beta-catenin acts as suppressor of invasion through a cell-type specific mechanism

Por Arozarena, Imanol, Bischof, Helen, Gilby, Daniel, Belloni, Benedetta, Dummer, Reinhard, Wellbrock, Claudia
Publicado em 2011

Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells

Por Arozarena, Imanol, Goicoechea, Ibai, Erice, Oihane, Ferguson, Jennnifer, Margison, Geoffrey P, Wellbrock, Claudia
Publicado em 2014

The Brn-2 Transcription Factor Links Activated BRAF to Melanoma Proliferation

Por Goodall, Jane, Wellbrock, Claudia, Dexter, Timothy J., Roberts, Karen, Marais, Richard, Goding, Colin R.
Publicado em 2004

Heterogeneous Tumor Subpopulations Cooperate to Drive Invasion

Por Chapman, Anna, Fernandez del Ama, Laura, Ferguson, Jennifer, Kamarashev, Jivko, Wellbrock, Claudia, Hurlstone, Adam
Publicado no Cell Rep (2014)

Collagen abundance controls melanoma phenotypes through lineage-specific microenvironment sensing

Por Miskolczi, Zsofia, Smith, Michael P., Rowling, Emily J., Ferguson, Jennifer, Barriuso, Jorge, Wellbrock, Claudia
Publicado no Oncogene (2018)

Apoptosis Suppression by Raf-1 and MEK1 Requires MEK- and Phosphatidylinositol 3-Kinase-Dependent Signals

Por von Gise, Alexander, Lorenz, Petra, Wellbrock, Claudia, Hemmings, Brian, Berberich-Siebelt, Friederike, Rapp, Ulf R., Troppmair, Jakob
Publicado em 2001

Effect of SMURF2 Targeting on Susceptibility to MEK Inhibitors in Melanoma

Por Smith, Michael P., Ferguson, Jennifer, Arozarena, Imanol, Hayward, Robert, Marais, Richard, Chapman, Anna, Hurlstone, Adam, Wellbrock, Claudia
Publicado em 2013

The melanocortin receptor agonist NDP-MSH impairs the allostimulatory function of dendritic cells

Por Rennalls, La’Verne P, Seidl, Thomas, Larkin, James M G, Wellbrock, Claudia, Gore, Martin E, Eisen, Tim, Bruno, Ludovica
Publicado em 2010

A PAX3/BRN2 rheostat controls the dynamics of BRAF mediated MITF regulation in MITF(high)/AXL(low) melanoma

Por Smith, Michael P., Rana, Sareena, Ferguson, Jennifer, Rowling, Emily J., Flaherty, Keith T., Wargo, Jennifer A., Marais, Richard, Wellbrock, Claudia
Publicado no Pigment Cell Melanoma Res (2018)