A PAX3/BRN2 rheostat controls the dynamics of BRAF mediated MITF regulation in MITF(high)/AXL(low) melanoma

The BRAF kinase and the MAPK pathway are targets of current melanoma therapies. However, MAPK pathway inhibition results in dynamic changes of downstream targets that can counteract inhibitor‐action not only in during treatment, but also in acquired resistant tumours. One such dynamic change involve...

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Vydáno v:Pigment Cell Melanoma Res
Hlavní autoři: Smith, Michael P., Rana, Sareena, Ferguson, Jennifer, Rowling, Emily J., Flaherty, Keith T., Wargo, Jennifer A., Marais, Richard, Wellbrock, Claudia
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6392120/
https://ncbi.nlm.nih.gov/pubmed/30277012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12741
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