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Effect of SMURF2 Targeting on Susceptibility to MEK Inhibitors in Melanoma
BACKGROUND: The mitogen-activated protein–kinase pathway consisting of the kinases RAF, MEK, and ERK is central to cell proliferation and survival and is deregulated in more than 90% of melanomas. MEK inhibitors are currently trialled in the clinic, but despite efficient target inhibition, cytostati...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3536641/ https://ncbi.nlm.nih.gov/pubmed/23250956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djs471 |
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