Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells

BACKGROUND: The importance of the genetic background of cancer cells for the individual susceptibility to cancer treatments is increasingly apparent. In melanoma, the existence of a BRAF mutation is a main predictor for successful BRAF-targeted therapy. However, despite initial successes with these...

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Autores principales: Arozarena, Imanol, Goicoechea, Ibai, Erice, Oihane, Ferguson, Jennnifer, Margison, Geoffrey P, Wellbrock, Claudia
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4079649/
https://ncbi.nlm.nih.gov/pubmed/24941944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-154
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