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Elevated expression of MITF counteracts B-RAF–stimulated melanocyte and melanoma cell proliferation
The protein kinase B-RAF is a human oncogene that is mutated in ∼70% of human melanomas and transforms mouse melanocytes. Microphthalmia-associated transcription factor (MITF) is an important melanocyte differentiation and survival factor, but its role in melanoma is unclear. In this study, we show...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2005
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2171350/ https://ncbi.nlm.nih.gov/pubmed/16129781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200505059 |
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