mTOR Mediated Anti-Cancer Drug Discovery

Por Liu, Qingsong, Thoreen, Carson, Wang, Jinhua, Sabatini, David, Gray, Nathanael S.
Publicado em 2009

La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region

Por Philippe, Lucas, Vasseur, Jean-Jacques, Debart, Françoise, Thoreen, Carson C
Publicado no Nucleic Acids Res (2018)

mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4

Por Park, Yeonwoo, Reyna-Neyra, Andrea, Philippe, Lucas, Thoreen, Carson C.
Publicado no Cell Rep (2017)

A unifying model for mTORC1-mediated regulation of mRNA translation

Por Thoreen, Carson C., Chantranupong, Lynne, Keys, Heather R., Wang, Tim, Gray, Nathanael S., Sabatini, David M.
Publicado em 2012

Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective and orally available mTOR inhibitor for treatm...

Por Liu, Qingsong, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Hur, Wooyoung, Ahmed, Tausif, Sabatini, David M., Gray, Nathanael S.
Publicado em 2011

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

Por Sancak, Yasemin, Peterson, Timothy R., Shaul, Yoav D., Lindquist, Robert A., Thoreen, Carson C., Bar-Peled, Liron, Sabatini, David M.
Publicado em 2008

DEPTOR is an mTOR Inhibitor Whose Frequent Overexpression in Multiple Myeloma Cells Promotes their Survival

Por Peterson, Timothy R., Laplante, Mathieu, Thoreen, Carson C., Sancak, Yasemin, Kang, Seong A., Kuehl, W. Michael, Gray, Nathanael S., Sabatini, David M.
Publicado em 2009

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

Por Thoreen, Carson C., Kang, Seong A., Chang, Jae Won, Liu, Qingsong, Zhang, Jianming, Gao, Yi, Reichling, Laurie J., Sim, Taebo, Sabatini, David M., Gray, Nathanael S.
Publicado em 2009

Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability

Por Liu, Qingsong, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Hur, Wooyoung, Choi, Hwan Geun, Waller, David L., Sim, Taebo, Sabatini, David M., Gray, Nathanael S.
Publicado em 2011

Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective Mammalian Target of Rapa...

Por Liu, Qingsong, Chang, Jae Won, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Markhard, Andrew, Hur, Wooyoung, Zhang, Jianming, Sim, Taebo, Sabatini, David M., Gray, Nathanael S.
Publicado em 2010

Development of ATP-competitive mTOR Inhibitors

Por Liu, Qingsong, Kang, Seong A., Thoreen, Carson C., Hur, Wooyoung, Wang, Jinhua, Chang, Jae Won, Markhard, Andrew, Zhang, Jianming, Sim, Taebo, Sabatini, David M., Gray, Nathanael S.
Publicado em 2012

ERK and p38 MAPK activities determine sensitivity to PI3K/mTOR inhibition via regulation of MYC and YAP

Por Muranen, Taru, Selfors, Laura M., Hwang, Julie, Gallegos, Lisa L., Coloff, Jonathan L., Thoreen, Carson C., Kang, Seong A., Sabatini, David M., Mills, Gordon B., Brugge, Joan S.
Publicado no Cancer Res (2016)

Cooperative nutrient accumulation sustains growth of mammalian cells

Por Son, Sungmin, Stevens, Mark M., Chao, Hui Xiao, Thoreen, Carson, Hosios, Aaron M., Schweitzer, Lawrence D., Weng, Yaochung, Wood, Kris, Sabatini, David, Vander Heiden, Matthew G., Manalis, Scott
Publicado no Sci Rep (2015)

Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1–S6K pathway signaling

Por Lindquist, Robert A., Ottina, Kathleen A., Wheeler, Douglas B., Hsu, Peggy P., Thoreen, Carson C., Guertin, David A., Ali, Siraj M., Sengupta, Shomit, Shaul, Yoav D., Lamprecht, Michael R., Madden, Katherine L., Papallo, Adam R., Jones, Thouis R., Sabatini, David M., Carpenter, Anne E.
Publicado em 2011

Kinome-wide Selectivity Profiling of ATP-competitive Mammalian Target of Rapamycin (mTOR) Inhibitors and Characterization of Their Binding Kinetics

Por Liu, Qingsong, Kirubakaran, Sivapriya, Hur, Wooyoung, Niepel, Mario, Westover, Kenneth, Thoreen, Carson C., Wang, Jinhua, Ni, Jing, Patricelli, Matthew P., Vogel, Kurt, Riddle, Steve, Waller, David L., Traynor, Ryan, Sanda, Takaomi, Zhao, Zheng, Kang, Seong A., Zhao, Jean, Look, A. Thomas, Sorger, Peter K., Sabatini, David M., Gray, Nathanael S.
Publicado em 2012

Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM and ATR

Por Liu, Qingsong, Xu, Chunxiao, Kirubakaran, Sivapriya, Zhang, Xin, Hur, Wooyoung, Liu, Yan, Kwiatkowski, Nicholas P., Wang, Jinhua, Westover, Kenneth D., Gao, Peng, Ercan, Dalia, Niepel, Mario, Thoreen, Carson C., Kang, Seong A., Patricelli, Matthew P., Wang, Yuchuan, Tupper, Tanya, Altabef, Abigail, Kawamura, Hidemasa, Held, Kathryn D., Chou, Danny M., Elledge, Stephen J., Janne, Pasi A., Wong, Kwok-Kin, Sabatini, David M., Gray, Nathanael S.
Publicado em 2013