BCL2 inhibitors as anticancer drugs: a plethora of misleading BH3 mimetics

Por Soderquist, Ryan S., Eastman, Alan
Publicado no Mol Cancer Ther (2016)

Central nervous system delivery of large molecules: challenges and new frontiers for intrathecally administered therapeutics

Por Soderquist, Ryan G., Mahoney, Melissa J.
Publicado em 2010

Gossypol Increases Expression of the Pro-apoptotic BH3-only Protein NOXA through a Novel Mechanism Involving Phospholipase A2, Cytoplasmic Calcium, and Endoplasmic Reticulum Stress

Por Soderquist, Ryan S., Danilov, Alexey V., Eastman, Alan
Publicado em 2014

Genetic analysis of the Replication Protein A large subunit family in Arabidopsis reveals unique and overlapping roles in DNA repair, meiosis and DNA replication

Por Aklilu, Behailu B., Soderquist, Ryan S., Culligan, Kevin M.
Publicado em 2014

Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477

Por Mallick, David J., Soderquist, Ryan S., Bates, Darcy, Eastman, Alan
Publicado no Cell Death Dis (2019)

The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA

Por Soderquist, Ryan, Pletnev, Alexandre A., Danilov, Alexey V., Eastman, Alan
Publicado em 2014

Toward a cure for chronic lymphocytic leukemia: an attack on multiple fronts

Por Danilov, Alexey V, Soderquist, Ryan S, Bates, Darcy JP, Eastman, Alan
Publicado em 2013

Spinal Interleukin-10 Therapy to Treat Peripheral Neuropathic Pain

Por Milligan, Erin D., Penzkover, Kathryn R., Soderquist, Ryan G., Mahoney, Melissa J.
Publicado em 2012

Multiple BH3 Mimetics Antagonize Antiapoptotic MCL1 Protein by Inducing the Endoplasmic Reticulum Stress Response and Up-regulating BH3-only Protein NOXA

Por Albershardt, Tina C., Salerni, Bethany L., Soderquist, Ryan S., Bates, Darcy J. P., Pletnev, Alexandre A., Kisselev, Alexei F., Eastman, Alan
Publicado em 2011

Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells

Por Wood, Matthew, Rawe, Melissa, Johansson, Gunnar, Pang, Shu, Soderquist, Ryan S., Patel, Ami V., Nelson, Sandra, Seibel, William, Ratner, Nancy, Sanchez, Yolanda
Publicado em 2011

PEGylation of interleukin-10 for the mitigation of enhanced pain states

Por Soderquist, Ryan G., Milligan, Erin D., Harrison, Jacqueline A., Chavez, Raymond A., Johnson, Kirk W., Watkins, Linda R., Mahoney, Melissa J.
Publicado em 2010

Cyclin-Dependent Kinase Inhibitor P1446A Induces Apoptosis in a JNK/p38 MAPK-Dependent Manner in Chronic Lymphocytic Leukemia B-Cells

Por Paiva, Cody, Godbersen, J. Claire, Soderquist, Ryan S., Rowland, Taylor, Kilmarx, Sumner, Spurgeon, Stephen E., Brown, Jennifer R., Srinivasa, Sreesha P., Danilov, Alexey V.
Publicado no PLoS One (2015)

Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity

Por Soderquist, Ryan S., Crawford, Lorin, Liu, Esther, Lu, Min, Agarwal, Anika, Anderson, Gray R., Lin, Kevin H., Winter, Peter S., Cakir, Merve, Wood, Kris C.
Publicado no Nat Commun (2018)

PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution

Por Soderquist, Ryan G., Milligan, Erin D., Sloane, Evan M., Harrison, Jacqueline A., Douvas, Klarika K., Potter, Joseph M., Hughes, Travis S., Chavez, Raymond A., Johnson, Kirk, Watkins, Linda R., Mahoney, Melissa J.
Publicado em 2009

Intrathecal polymer-based interleukin-10 gene delivery for neuropathic pain

Por MILLIGAN, ERIN D., SODERQUIST, RYAN G., MALONE, STEPHANIE M., MAHONEY, JOHN H., HUGHES, TRAVIS S., LANGER, STEPHEN J., SLOANE, EVAN M., MAIER, STEVEN F., LEINWAND, LESLIE A., WATKINS, LINDA R., MAHONEY, MELISSA J.
Publicado em 2006

Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models

Por Manzari, Mandana T., Anderson, Grace R., Lin, Kevin H., Soderquist, Ryan S., Çakir, Merve, Zhang, Mitchell, Moore, Chandler E., Skelton, Rachel N., Fèvre, Maréva, Li, Xinghai, Bellucci, Joseph J., Wardell, Suzanne E., Costa, Simone A., Wood, Kris C., Chilkoti, Ashutosh
Publicado no Sci Adv (2019)

Release of Plasmid DNA-Encoding IL-10 from PLGA Microparticles Facilitates Long-Term Reversal of Neuropathic Pain Following a Single Intrathecal Administration

Por Soderquist, Ryan Gene, Sloane, Evan M., Loram, Lisa C., Harrison, Jacqueline A., Dengler, Ellen C., Johnson, Scott M., Amer, Luke D., Young, Courtney S., Lewis, Makenzie T., Poole, Stephen, Frank, Matthew G., Watkins, Linda R., Milligan, Erin D., Mahoney, Melissa J.
Publicado em 2010

Systematic dissection of the metabolic-apoptotic interface in AML reveals heme biosynthesis to be a regulator of drug sensitivity

Por Lin, Kevin H., Xie, Abigail, Rutter, Justine C., Ahn, Yeong-ran, Lloyd-Cowden, Julia M., Nichols, Amanda G., Soderquist, Ryan S., Koves, Timothy R., Muoio, Deborah, MacIver, Nancie J., Lamba, Jatinder, Pardee, Timothy S., McCall, Chad M., Rizzieri, David A., Wood, Kris C.
Publicado no Cell Metab (2019)

PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation

Por Anderson, Grace R., Wardell, Suzanne E., Cakir, Merve, Crawford, Lorin, Leeds, Jim C., Nussbaum, Daniel P., Shankar, Pallavi S., Soderquist, Ryan S., Stein, Elizabeth M., Tingley, Jennifer P., Winter, Peter S., Zieser-Misenheimer, Elizabeth K., Alley, Holly M., Yllanes, Alexander, Haney, Victoria, Blackwell, Kimberly L., McCall, Shannon J., McDonnell, Donald P., Wood, Kris C.
Publicado no Sci Transl Med (2016)

A landscape of therapeutic cooperativity in KRAS mutant cancers reveals principles for controlling tumor evolution

Por Anderson, Grace R., Winter, Peter S., Lin, Kevin H., Nussbaum, Daniel P., Cakir, Merve, Stein, Elizabeth M., Soderquist, Ryan S., Crawford, Lorin, Leeds, Jim C., Newcomb, Rachel, Stepp, Priya, Yip, Catherine, Wardell, Suzanne E., Tingley, Jennifer P., Ali, Moiez, Xu, Mengmeng, Ryan, Meagan, McCall, Shannon J., McRee, Autumn J., Counter, Christopher M., Der, Channing J., Wood, Kris C.
Publicado no Cell Rep (2017)