Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity

While inhibitors of BCL-2 family proteins (BH3 mimetics) have shown promise as anti-cancer agents, the various dependencies or co-dependencies of diverse cancers on BCL-2 genes remain poorly understood. Here we develop a drug screening approach to define the sensitivity of cancer cells from ten tiss...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Soderquist, Ryan S., Crawford, Lorin, Liu, Esther, Lu, Min, Agarwal, Anika, Anderson, Gray R., Lin, Kevin H., Winter, Peter S., Cakir, Merve, Wood, Kris C.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6115427/
https://ncbi.nlm.nih.gov/pubmed/30158527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05815-z
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki