Загрузка...

BCL2 inhibitors as anticancer drugs: a plethora of misleading BH3 mimetics

Anti-apoptotic BCL2 proteins play a major role in tumor cell survival. Hence, BCL2 inhibitors have been developed as direct inducers of apoptosis. ABT-199 (venetoclax) received breakthrough therapy designation from the FDA due to its apparent efficacy in CLL and AML. However, resistance to ABT-199 i...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Mol Cancer Ther
Главные авторы: Soderquist, Ryan S., Eastman, Alan
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010924/
https://ncbi.nlm.nih.gov/pubmed/27535975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0031
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!