Загрузка...
Confounding off-target effects of BH3 mimetics at commonly used concentrations: MIM1, UMI-77, and A-1210477
Targeting anti-apoptotic BCL2 family proteins has become an attractive therapeutic strategy for many cancers, and the BCL2-selective inhibitor ABT-199 (venetoclax) has obtained clinical success. However, MCL1 can promote drug resistance and overall cancer cell survival. Thus, there is a critical nee...
Сохранить в:
| Опубликовано в: : | Cell Death Dis |
|---|---|
| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2019
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6385300/ https://ncbi.nlm.nih.gov/pubmed/30796196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1426-3 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|