Wird geladen...

BCL2 inhibitors as anticancer drugs: a plethora of misleading BH3 mimetics

Anti-apoptotic BCL2 proteins play a major role in tumor cell survival. Hence, BCL2 inhibitors have been developed as direct inducers of apoptosis. ABT-199 (venetoclax) received breakthrough therapy designation from the FDA due to its apparent efficacy in CLL and AML. However, resistance to ABT-199 i...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Soderquist, Ryan S., Eastman, Alan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010924/
https://ncbi.nlm.nih.gov/pubmed/27535975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0031
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!