The BCL-2 protein family, BH3-mimetics and cancer therapy

Escape from apoptosis is a key attribute of tumour cells and facilitates chemo-resistance. The ‘BCL-2-regulated' or ‘intrinsic' apoptotic pathway integrates stress and survival signalling to govern whether a cancer cell will live or die. Indeed, many pro-apoptotic members of the BCL-2 fami...

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Bibliografiske detaljer
Udgivet i:Cell Death Differ
Main Authors: Delbridge, A R D, Strasser, A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572872/
https://ncbi.nlm.nih.gov/pubmed/25952548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.50
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