The molecular mechanisms underlying the pharmacological actions of ER modulators: Implications for new drug discovery in breast cancer

Por McDonnell, Donald P., Wardell, Suzanne E.
Publicado em 2010

Research Resource: Transcriptional Profiling in a Cellular Model of Breast Cancer Reveals Functional and Mechanistic Differences Between Clinically Relevant SERM and Between SERM/E...

Por Wardell, Suzanne E., Kazmin, Dmitri, McDonnell, Donald P.
Publicado em 2012

The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy

Por Wardell, Suzanne E., Marks, Jeffrey R., McDonnell, Donald P.
Publicado em 2011

The Molecular Mechanisms Underlying the Pharmacological Actions of Estrogens, SERMs and Oxysterols: Implications for the Treatment and Prevention of Osteoporosis

Por Nelson, Erik R., Wardell, Suzanne E., McDonnell, Donald P.
Publicado em 2012

From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs)

Por Wardell, Suzanne E., Nelson, Erik R., McDonnell, Donald P.
Publicado em 2014

Oral selective estrogen receptor downregulators (SERDs) a breakthrough endocrine therapy for breast cancer

Por McDonnell, Donald P., Wardell, Suzanne E., Norris, John D.
Publicado no J Med Chem (2015)

Partial Agonist Activity of the Progesterone Receptor Antagonist RU486 Mediated by an Amino-Terminal Domain Coactivator and Phosphorylation of Serine(400)

Por Wardell, Suzanne E., Narayanan, Ramesh, Weigel, Nancy L., Edwards, Dean P.
Publicado em 2010

Jun Dimerization Protein 2 Functions as a Progesterone Receptor N-Terminal Domain Coactivator

Por Wardell, Suzanne E., Boonyaratanakornkit, Viroj, Adelman, James S., Aronheim, Ami, Edwards, Dean P.
Publicado em 2002

Regulation of the Amino-Terminal Transcription Activation Domain of Progesterone Receptor by a Cofactor-Induced Protein Folding Mechanism

Por Wardell, Suzanne E., Kwok, Stanley C., Sherman, Lori, Hodges, Robert S., Edwards, Dean P.
Publicado em 2005

Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen resistant breast cancer; implications for treatment of advanced disease

Por Wardell, Suzanne E., Nelson, Erik R., Chao, Christina A., McDonnell, Donald P.
Publicado em 2013

Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader

Por Wardell, Suzanne E., Nelson, Erik R., Chao, Christina A., Alley, Holly M., McDonnell, Donald P.
Publicado no Endocr Relat Cancer (2015)

Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer

Por Wright, Tricia M, Wardell, Suzanne E, Jasper, Jeff S, Stice, James P, Safi, Rachid, Nelson, Erik R, McDonnell, Donald P
Publicado no Mol Cancer Res (2014)

Glucose Metabolism as a Target of Histone Deacetylase Inhibitors

Por Wardell, Suzanne E., Ilkayeva, Olga R., Wieman, Heather L., Frigo, Daniel E., Rathmell, Jeffrey C., Newgard, Christopher B., McDonnell, Donald P.
Publicado em 2009

Obesity, Cholesterol Metabolism and Breast Cancer Pathogenesis

Por McDonnell, Donald P., Park, Sunghee, Goulet, Matthew T., Jasper, Jeff, Wardell, Suzanne E., Chang, Ching-yi, Norris, John D., Guyton, John R., Nelson, Erik R.
Publicado em 2014

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

Por Nelson, Erik R., Wardell, Suzanne E., Jasper, Jeff S., Park, Sunghee, Suchindran, Sunil, Howe, Matthew K., Carver, Nicole J., Pillai, Ruchita V., Sullivan, Patrick M., Sondhi, Varun, Umetani, Michihisa, Geradts, Joseph, McDonnell, Donald P.
Publicado em 2013

Efficacy of SERD/SERM Hybrid-CDK4/6 inhibitor combinations in models of endocrine therapy resistant breast cancer

Por Wardell, Suzanne E., Ellis, Matthew J., Alley, Holly M., Eisele, Koleen, VanArsdale, Todd, Dann, Stephen G., Arndt, Kim T., Primeau, Tina, Griffin, Elizabeth, Shao, Jieya, Crowder, Robert, Lai, Jin-Ping, Norris, John D., McDonnell, Donald P., Li, Shunqiang
Publicado no Clin Cancer Res (2015)

Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer

Por Pollock, Julie A., Wardell, Suzanne E., Parent, Alexander A., Stagg, David B., Ellison, Stephanie J., Alley, Holly M., Chao, Christina A., Lawrence, Scott A., Stice, James P., Spasojevic, Ivan, Baker, Jennifer G., Kim, Sung Hoon, McDonnell, Donald P., Katzenellenbogen, John A., Norris, John D.
Publicado no Nat Chem Biol (2016)

Systematic identification of signaling pathways with potential to confer anticancer drug resistance

Por Martz, Colin A., Ottina, Kathleen A., Singleton, Katherine R., Jasper, Jeff S., Wardell, Suzanne E., Peraza-Penton, Ashley, Anderson, Grace R., Winter, Peter S., Wang, Tim, Alley, Holly M., Kwong, Lawrence N., Cooper, Zachary A., Tetzlaff, Michael, Chen, Pei-Ling, Rathmell, Jeffrey C., Flaherty, Keith T., Wargo, Jennifer A., McDonnell, Donald P., Sabatini, David M., Wood, Kris C.
Publicado no Sci Signal (2014)