Systematic identification of signaling pathways with potential to confer anticancer drug resistance

Cancer cells can activate diverse signaling pathways to evade the cytotoxic action of drugs. We created and screened a library of barcoded pathway-activating mutant cDNAs to identify those that enhanced the survival of cancer cells in the presence of 13 clinically relevant, targeted therapies. We fo...

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Detalhes bibliográficos
Publicado no:Sci Signal
Main Authors: Martz, Colin A., Ottina, Kathleen A., Singleton, Katherine R., Jasper, Jeff S., Wardell, Suzanne E., Peraza-Penton, Ashley, Anderson, Grace R., Winter, Peter S., Wang, Tim, Alley, Holly M., Kwong, Lawrence N., Cooper, Zachary A., Tetzlaff, Michael, Chen, Pei-Ling, Rathmell, Jeffrey C., Flaherty, Keith T., Wargo, Jennifer A., McDonnell, Donald P., Sabatini, David M., Wood, Kris C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353587/
https://ncbi.nlm.nih.gov/pubmed/25538079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa1877
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