27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

Hypercholesterolemia is a risk factor for estrogen receptor (ER) positive breast cancers and is associated with a decreased response of tumors to endocrine therapies. Here we show that 27-Hydroxycholesterol (27HC), a primary metabolite of cholesterol and an ER and Liver X receptor (LXR) ligand, incr...

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Autors principals: Nelson, Erik R., Wardell, Suzanne E., Jasper, Jeff S., Park, Sunghee, Suchindran, Sunil, Howe, Matthew K., Carver, Nicole J., Pillai, Ruchita V., Sullivan, Patrick M., Sondhi, Varun, Umetani, Michihisa, Geradts, Joseph, McDonnell, Donald P.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899689/
https://ncbi.nlm.nih.gov/pubmed/24288332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1241908
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