27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

Hypercholesterolemia is a risk factor for estrogen receptor (ER) positive breast cancers and is associated with a decreased response of tumors to endocrine therapies. Here we show that 27-Hydroxycholesterol (27HC), a primary metabolite of cholesterol and an ER and Liver X receptor (LXR) ligand, incr...

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Hlavní autoři: Nelson, Erik R., Wardell, Suzanne E., Jasper, Jeff S., Park, Sunghee, Suchindran, Sunil, Howe, Matthew K., Carver, Nicole J., Pillai, Ruchita V., Sullivan, Patrick M., Sondhi, Varun, Umetani, Michihisa, Geradts, Joseph, McDonnell, Donald P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3899689/
https://ncbi.nlm.nih.gov/pubmed/24288332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1241908
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