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Partial Agonist Activity of the Progesterone Receptor Antagonist RU486 Mediated by an Amino-Terminal Domain Coactivator and Phosphorylation of Serine(400)

Jun dimerization protein-2 (JDP-2) is a progesterone receptor (PR) coregulatory protein that acts by inducing structure and transcriptional activity in the disordered amino-terminal domain (NTD) of PR. JDP-2 can also potentiate the partial agonist activity of the PR antagonist RU486 by mechanisms th...

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Detalhes bibliográficos
Main Authors: Wardell, Suzanne E., Narayanan, Ramesh, Weigel, Nancy L., Edwards, Dean P.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817605/
https://ncbi.nlm.nih.gov/pubmed/20008003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0081
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