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The X-ray Structure of RU486 Bound to the Progesterone Receptor in a Destabilized Agonistic Conformation
Here we describe the 1.95 Å structure of the clinically used antiprogestin RU486 (mifepristone) in complex with the progesterone receptor (PR). The structure was obtained by taking a crystal of the PR ligand binding domain containing the agonist norethindrone and soaking it in a solution containing...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2740583/ https://ncbi.nlm.nih.gov/pubmed/19372222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.007872 |
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