The X-ray Structure of RU486 Bound to the Progesterone Receptor in a Destabilized Agonistic Conformation

Here we describe the 1.95 Å structure of the clinically used antiprogestin RU486 (mifepristone) in complex with the progesterone receptor (PR). The structure was obtained by taking a crystal of the PR ligand binding domain containing the agonist norethindrone and soaking it in a solution containing...

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Bibliografiske detaljer
Main Authors: Raaijmakers, Hans C. A., Versteegh, Judith E., Uitdehaag, Joost C. M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740583/
https://ncbi.nlm.nih.gov/pubmed/19372222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.007872
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