16 alpha-substituted analogs of the antiprogestin RU486 induce a unique conformation in the human progesterone receptor resulting in mixed agonist activity.

Previously, we have shown that agonists and antagonists interact with distinct, though overlapping regions within the human progesterone receptor (hPR) resulting in the formation of structurally different complexes. Thus, a link was established between the structure of a ligand-receptor complex and...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Wagner, B L, Pollio, G, Leonhardt, S, Wani, M C, Lee, D Y, Imhof, M O, Edwards, D P, Cook, C E, McDonnell, D P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38743/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8710941/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.16.8739
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