PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution

Brain-derived neurotrophic factor (BDNF) was covalently attached to polyethylene glycol (PEG) in order to enhance delivery to the spinal cord via the cerebrospinal fluid (intrathecal administration). By varying reaction conditions, mixtures of BDNF covalently attached to one (primary), two (secondar...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Soderquist, Ryan G., Milligan, Erin D., Sloane, Evan M., Harrison, Jacqueline A., Douvas, Klarika K., Potter, Joseph M., Hughes, Travis S., Chavez, Raymond A., Johnson, Kirk, Watkins, Linda R., Mahoney, Melissa J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990442/
https://ncbi.nlm.nih.gov/pubmed/19048635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm.a.32254
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky