Intrathecal Injection of Naked Plasmid DNA Provides Long-term Expression of Secreted Proteins

Therapeutic benefit has been reported to result from intrathecal (i.t.) injection of transgene vectors, including naked DNA. However, most studies using naked DNA have measured only the transgene expression of intracellular proteins. Here we demonstrate that i.t. injection of naked DNA can result in...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Hughes, Travis S, Langer, Stephen J, Johnson, Kirk W, Chavez, Raymond A, Watkins, Linda R, Milligan, Erin D, Leinwand, Leslie A
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2008
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834984/
https://ncbi.nlm.nih.gov/pubmed/18941439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.230
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