Intrathecal Injection of Naked Plasmid DNA Provides Long-term Expression of Secreted Proteins

Therapeutic benefit has been reported to result from intrathecal (i.t.) injection of transgene vectors, including naked DNA. However, most studies using naked DNA have measured only the transgene expression of intracellular proteins. Here we demonstrate that i.t. injection of naked DNA can result in...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hughes, Travis S, Langer, Stephen J, Johnson, Kirk W, Chavez, Raymond A, Watkins, Linda R, Milligan, Erin D, Leinwand, Leslie A
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2008
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834984/
https://ncbi.nlm.nih.gov/pubmed/18941439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.230
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