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Intrathecal Interleukin-10 Gene Therapy Attenuates Paclitaxel-Induced Mechanical Allodynia and Proinflammatory Cytokine Expression in Dorsal Root Ganglia in Rats

Paclitaxel is a commonly used cancer chemotherapy drug that frequently causes painful peripheral neuropathies. The mechanisms underlying this dose-limiting side effect are poorly understood. Growing evidence supports that proinflammatory cytokines, such as interleukin-1 (IL-1) and tumor necrosis fac...

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Detalhes bibliográficos
Main Authors: Ledeboer, Annemarie, Jekich, Brian M., Sloane, Evan M., Mahoney, John H., Langer, Stephen J., Milligan, Erin D., Martin, David, Maier, Steven F., Johnson, Kirk W., Leinwand, Leslie A., Chavez, Raymond A., Watkins, Linda R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063454/
https://ncbi.nlm.nih.gov/pubmed/17174526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2006.10.012
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