Immunological priming potentiates non-viral anti-inflammatory gene therapy treatment of neuropathic pain: Harnessing innate immunity to enhance gene therapy

We recently described a non-viral gene therapy paradigm offering long-term resolution of established neuropathic pain in several animal models. Here, the requirements for long term therapeutic effects are described, and evidence is provided for a mechanism of action based on immunological priming of...

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Main Authors: Sloane, Evan, Langer, Steve, Jekich, Brian, Mahoney, John, Hughes, Travis, Frank, Matthew, Seibert, Whitney, Huberty, Garth, Coats, Benjamen, Harrison, Jackie, Klinman, Dennis, Poole, Steven, Maier, Steven, Johnson, Kirk, Chavez, Ray, Watkins, Linda, Leinwand, Leslie, Milligan, Erin
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2762489/
https://ncbi.nlm.nih.gov/pubmed/19571887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2009.79
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