Intrathecal Injection of Naked Plasmid DNA Provides Long-term Expression of Secreted Proteins

Therapeutic benefit has been reported to result from intrathecal (i.t.) injection of transgene vectors, including naked DNA. However, most studies using naked DNA have measured only the transgene expression of intracellular proteins. Here we demonstrate that i.t. injection of naked DNA can result in...

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Autori principali: Hughes, Travis S, Langer, Stephen J, Johnson, Kirk W, Chavez, Raymond A, Watkins, Linda R, Milligan, Erin D, Leinwand, Leslie A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2008
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834984/
https://ncbi.nlm.nih.gov/pubmed/18941439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.230
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