Intrathecal Injection of Naked Plasmid DNA Provides Long-term Expression of Secreted Proteins

Therapeutic benefit has been reported to result from intrathecal (i.t.) injection of transgene vectors, including naked DNA. However, most studies using naked DNA have measured only the transgene expression of intracellular proteins. Here we demonstrate that i.t. injection of naked DNA can result in...

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Detalhes bibliográficos
Main Authors: Hughes, Travis S, Langer, Stephen J, Johnson, Kirk W, Chavez, Raymond A, Watkins, Linda R, Milligan, Erin D, Leinwand, Leslie A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834984/
https://ncbi.nlm.nih.gov/pubmed/18941439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.230
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