PEGylation of interleukin-10 for the mitigation of enhanced pain states

The anti-inflammatory cytokine interleukin-10 (IL-10) shows promise for the treatment of neuropathic pain, but for IL-10 to be clinically useful as a short-term therapeutic its duration needs to be improved. In this study, IL-10 was covalently modified with polyethylene glycol (PEG) with the goal of...

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Main Authors: Soderquist, Ryan G., Milligan, Erin D., Harrison, Jacqueline A., Chavez, Raymond A., Johnson, Kirk W., Watkins, Linda R., Mahoney, Melissa J.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604983/
https://ncbi.nlm.nih.gov/pubmed/19768789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm.a.32611
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