PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution

Brain-derived neurotrophic factor (BDNF) was covalently attached to polyethylene glycol (PEG) in order to enhance delivery to the spinal cord via the cerebrospinal fluid (intrathecal administration). By varying reaction conditions, mixtures of BDNF covalently attached to one (primary), two (secondar...

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Main Authors: Soderquist, Ryan G., Milligan, Erin D., Sloane, Evan M., Harrison, Jacqueline A., Douvas, Klarika K., Potter, Joseph M., Hughes, Travis S., Chavez, Raymond A., Johnson, Kirk, Watkins, Linda R., Mahoney, Melissa J.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990442/
https://ncbi.nlm.nih.gov/pubmed/19048635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm.a.32254
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