PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution

Brain-derived neurotrophic factor (BDNF) was covalently attached to polyethylene glycol (PEG) in order to enhance delivery to the spinal cord via the cerebrospinal fluid (intrathecal administration). By varying reaction conditions, mixtures of BDNF covalently attached to one (primary), two (secondar...

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Main Authors: Soderquist, Ryan G., Milligan, Erin D., Sloane, Evan M., Harrison, Jacqueline A., Douvas, Klarika K., Potter, Joseph M., Hughes, Travis S., Chavez, Raymond A., Johnson, Kirk, Watkins, Linda R., Mahoney, Melissa J.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990442/
https://ncbi.nlm.nih.gov/pubmed/19048635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm.a.32254
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