A landscape of therapeutic cooperativity in KRAS mutant cancers reveals principles for controlling tumor evolution

Combinatorial inhibition of effector and feedback pathways is a promising treatment strategy for KRAS mutant cancers. However, the particular pathways that should be targeted to optimize therapeutic responses are unclear. Using CRISPR/Cas9, we systematically mapped the pathways whose inhibition coop...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Cell Rep
Main Authors: Anderson, Grace R., Winter, Peter S., Lin, Kevin H., Nussbaum, Daniel P., Cakir, Merve, Stein, Elizabeth M., Soderquist, Ryan S., Crawford, Lorin, Leeds, Jim C., Newcomb, Rachel, Stepp, Priya, Yip, Catherine, Wardell, Suzanne E., Tingley, Jennifer P., Ali, Moiez, Xu, Mengmeng, Ryan, Meagan, McCall, Shannon J., McRee, Autumn J., Counter, Christopher M., Der, Channing J., Wood, Kris C.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2017
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567854/
https://ncbi.nlm.nih.gov/pubmed/28746882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.07.006
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