Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells

Malignant peripheral nerve sheath tumor (MPNST) is a life-threatening complication of neurofibromatosis type 1 (NF1). NF1 is caused by mutation in the gene encoding neurofibromin, a negative regulator of Ras signaling. There are no effective pharmacologic therapies for MPNST. To identify new therape...

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Hlavní autoři: Wood, Matthew, Rawe, Melissa, Johansson, Gunnar, Pang, Shu, Soderquist, Ryan S., Patel, Ami V., Nelson, Sandra, Seibel, William, Ratner, Nancy, Sanchez, Yolanda
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3170489/
https://ncbi.nlm.nih.gov/pubmed/21697395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0309
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