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The C-terminal domains of human neurofibromin and its budding yeast homologs Ira1 and Ira2 regulate the metaphase to anaphase transition

The human tumor suppressor neurofibromin contains a cysteine and serine-rich domain/Ras-GTPase activating protein domain (CSRD/RasGAP) and a C-terminal domain (CTD). Domain studies of neurofibromin suggest it has other functions in addition to being a RasGAP, but the mechanisms underlying its tumor...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Luo, Guangming, Kim, Junwon, Song, Kiwon
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615033/
https://ncbi.nlm.nih.gov/pubmed/25486365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2015.945870
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