Introduction to Cancer Chemotherapeutics

Por Shewach, Donna S., Kuchta, Robert D.
Publicado em 2009

Detection of nucleotide disbalance in cells undergoing oncogene-induced senescence

Por Nikiforov, Mikhail A., Shewach, Donna S.
Publicado no Methods Mol Biol (2017)

Unrepairable DNA Double Strand Breaks Initiate Cytotoxicity with HSV-TK/Ganciclovir

Por Ladd, Brendon, O’Konek, Jessica J., Ostruszka, Leo J., Shewach, Donna S.
Publicado em 2011

Drug Metabolism and Homologous Recombination Repair in Radiosensitization with Gemcitabine

Por Im, Michael M., Flanagan, Sheryl A., Ackroyd, Jeffrey J., Shewach, Donna S.
Publicado no Radiat Res (2015)

shRNA suppression of thymidylate synthase produces DNA mismatches and results in excellent radiosensitization

Por Flanagan, Sheryl A., Cooper, Kristin S., Mannava, Sudha, Nikiforov, Mikhail A., Shewach, Donna S.
Publicado em 2012

MLH1 Deficiency Enhances Radiosensitization with 5-Fluorodeoxyuridine by Increasing DNA Mismatches

Por Flanagan, Sheryl A., Krokosky, Christina M., Mannava, Sudha, Nikiforov, Mikhail A., Shewach, Donna S.
Publicado em 2008

MLH1 Deficiency Enhances Tumor Cell Sensitivity to Ganciclovir

Por O’Konek, Jessica J., Boucher, Paul D., Iacco, Anthony A., Wilson, Thomas E., Shewach, Donna S.
Publicado em 2009

Inhibition of Homologous Recombination with Vorinostat Synergistically Enhances Ganciclovir Cytotoxicity

Por Ladd, Brendon, Ackroyd, Jeffrey J., Hicks, J. Kevin, Canman, Christine E., Flanagan, Sheryl A., Shewach, Donna S.
Publicado em 2013

Folate levels modulate oncogene-induced replication stress and tumorigenicity

Por Lamm, Noa, Maoz, Karin, Bester, Assaf C, Im, Michael M, Shewach, Donna S, Karni, Rotem, Kerem, Batsheva
Publicado no EMBO Mol Med (2015)

N-acetylgalactosamine-functionalized dendrimers as hepatic cancer cell-targeted carriers

Por Medina, Scott H., Tekumalla, Venkatesh, Chevliakov, Maxim V., Shewach, Donna S., Ensminger, William D., El-Sayed, Mohamed E.H.
Publicado em 2011

Metabolism in Human Cells of the d and l Enantiomers of the Carbocyclic Analog of 2′-Deoxyguanosine: Substrate Activity with Deoxycytidine Kinase, Mitochondrial Deoxyguanosine Kina...

Por Bennett, L. Lee, Allan, Paula W., Arnett, Gussie, Shealy, Y. Fulmer, Shewach, Donna S., Mason, William S., Fourel, Isabelle, Parker, William B.
Publicado em 1998

Alteration of the carbohydrate for deoxyguanosine analogs markedly changes DNA replication fidelity, cell cycle progression and cytotoxicity

Por O’Konek, Jessica J., Ladd, Brendon, Flanagan, Sheryl A., Im, Mike M., Boucher, Paul D., Thepsourinthone, Tico S., Secrist, John A., Shewach, Donna S.
Publicado em 2010

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

Por Bester, Assaf C., Roniger, Maayan, Oren, Yifat S., Im, Michael M., Sarni, Dan, Chaoat, Malka, Bensimon, Aaron, Zamir, Gideon, Shewach, Donna S., Kerem, Batsheva
Publicado em 2011

Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells

Por Mannava, Sudha, Grachtchouk, Vladimir, Wheeler, Linda J., Im, Michael, Zhuang, Dazhong, Slavina, Elena G., Mathews, Christopher K., Shewach, Donna S., Nikiforov, Mikhail A.
Publicado em 2008

Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule

Por Ahmad, Md. Faiz, Alam, Intekhab, Huff, Sarah E., Pink, John, Flanagan, Sheryl A., Shewach, Donna, Misko, Tessianna A., Oleinick, Nancy L., Harte, William E., Viswanathan, Rajesh, Harris, Michael E., Dealwis, Chris Godfrey
Publicado no Proc Natl Acad Sci U S A (2017)

Depletion of Deoxyribonucleotide Pools Is an Endogenous Source of DNA Damage in Cells Undergoing Oncogene-Induced Senescence

Por Mannava, Sudha, Moparthy, Kalyana C., Wheeler, Linda J., Natarajan, Venkatesh, Zucker, Shoshanna N., Fink, Emily E., Im, Michael, Flanagan, Sheryl, Burhans, William C., Zeitouni, Nathalie C., Shewach, Donna S., Mathews, Christopher K., Nikiforov, Mikhail A.
Publicado em 2013

Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion

Por Mannava, Sudha, Moparthy, Kalyana C., Wheeler, Linda J., Leonova, Katerina I., Wawrzyniak, Joseph A., Bianchi-Smiraglia, Anna, Berman, Albert E., Flanagan, Sheryl, Shewach, Donna S., Zeitouni, Nathalie C., Gudkov, Andrei V., Mathews, Christopher K., Nikiforov, Mikhail A.
Publicado em 2012

Microphthalmia-Associated Transcription Factor Suppresses Invasion by Reducing Intracellular GTP Pools

Por Bianchi-Smiraglia, Anna, Bagati, Archis, Fink, Emily E., Moparthy, Sudha, Wawrzyniak, Joseph A., Marvin, Elizabeth K., Battaglia, Sebastiano, Jowdy, Peter, Kolesnikova, Maria, Foley, Colleen E., Berman, Albert E., Kozlova, Nadezhda I., Lipchick, Brittany C., Paul-Rosner, Leslie M., Bshara, Wiam, Ackroy, Jeff, Shewach, Donna S., Nikiforov, Mikhail A.
Publicado no Oncogene (2016)

A Purine Nucleotide Biosynthesis Enzyme Guanosine Monophosphate Reductase is a Suppressor of Melanoma Invasion

Por Wawrzyniak, Joseph A., Bianchi-Smiraglia, Anna, Bshara, Wiam, Mannava, Sudha, Ackroyd, Jeff, Bagati, Archis, Omilian, Angela R., Im, Michael, Fedtsova, Natalia, Miecznikowski, Jeffrey C., Moparthy, Kalyana C., Zucker, Shoshanna N., Zhu, Qianqian, Kozlova, Nadezhda I., Berman, Albert E., Hoek, Keith S., Gudkov, Andrei V., Shewach, Donna S., Morrison, Carl D., Nikiforov, Mikhail A.
Publicado em 2013