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MLH1 Deficiency Enhances Tumor Cell Sensitivity to Ganciclovir
Suicide gene therapy with herpes simplex virus thymidine kinase and ganciclovir is notable for producing multi-log cytotoxicity in a unique pattern of delayed cytotoxicity in S-phase. Because hydroxyurea, a ribonucleotide reductase inhibitor that activates mismatch repair, can increase sensitivity t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3118284/ https://ncbi.nlm.nih.gov/pubmed/19300472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2009.16 |
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