Inhibition of Homologous Recombination with Vorinostat Synergistically Enhances Ganciclovir Cytotoxicity

The nucleoside analog ganciclovir (GCV) elicits cytotoxicity in tumor cells via a novel mechanism in which drug incorporation into DNA produces minimal disruption of replication, but numerous DNA double strand breaks occur during the second S-phase after drug exposure. We propose that homologous rec...

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Autori principali: Ladd, Brendon, Ackroyd, Jeffrey J., Hicks, J. Kevin, Canman, Christine E., Flanagan, Sheryl A., Shewach, Donna S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3922048/
https://ncbi.nlm.nih.gov/pubmed/24231389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.10.008
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