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Drug Metabolism and Homologous Recombination Repair in Radiosensitization with Gemcitabine

Gemcitabine (difluorodeoxycytidine; dFdCyd) is a potent radiosensitizer, noted for its ability to enhance cytotoxicity with radiation at noncytotoxic concentrations in vitro and subchemotherapeutic doses in patients. Radiosensitization in human tumor cells requires dFdCyd-mediated accumulation of ce...

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Detalhes bibliográficos
Publicado no:Radiat Res
Main Authors: Im, Michael M., Flanagan, Sheryl A., Ackroyd, Jeffrey J., Shewach, Donna S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4341824/
https://ncbi.nlm.nih.gov/pubmed/25564718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR13807.1
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