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shRNA suppression of thymidylate synthase produces DNA mismatches and results in excellent radiosensitization
PURPOSE: To determine the effect of shRNA-mediated suppression of thymidylate synthase (TS) on cytotoxicity and radiosensitization and the mechanism by which these events occur. METHODS AND MATERIALS: shRNA suppression of TS was compared to FdUrd inactivation of TS ± ionizing radiation in HCT116 and...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3494755/ https://ncbi.nlm.nih.gov/pubmed/22867891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2012.06.050 |
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