Improved siRNA/shRNA Functionality by Mismatched Duplex

siRNA (small interfering RNA) and shRNA (small hairpin RNA) are powerful and commonly used tools in biomedical research. Currently, siRNAs are generally designed as two 21 nt strands of RNA that include a 19 nt completely complementary part and a 2 nt overhang. However, since the si/shRNAs use the e...

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Detalhes bibliográficos
Main Authors: Wu, Haoquan, Ma, Hongming, Ye, Chunting, Ramirez, Danielle, Chen, Shuiping, Montoya, Jessica, Shankar, Premlata, Wang, Xiaozhong A., Manjunath, N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235145/
https://ncbi.nlm.nih.gov/pubmed/22174840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028580
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