Improved siRNA/shRNA Functionality by Mismatched Duplex

siRNA (small interfering RNA) and shRNA (small hairpin RNA) are powerful and commonly used tools in biomedical research. Currently, siRNAs are generally designed as two 21 nt strands of RNA that include a 19 nt completely complementary part and a 2 nt overhang. However, since the si/shRNAs use the e...

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Détails bibliographiques
Auteurs principaux: Wu, Haoquan, Ma, Hongming, Ye, Chunting, Ramirez, Danielle, Chen, Shuiping, Montoya, Jessica, Shankar, Premlata, Wang, Xiaozhong A., Manjunath, N.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235145/
https://ncbi.nlm.nih.gov/pubmed/22174840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028580
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