Improved siRNA/shRNA Functionality by Mismatched Duplex

siRNA (small interfering RNA) and shRNA (small hairpin RNA) are powerful and commonly used tools in biomedical research. Currently, siRNAs are generally designed as two 21 nt strands of RNA that include a 19 nt completely complementary part and a 2 nt overhang. However, since the si/shRNAs use the e...

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Detaylı Bibliyografya
Asıl Yazarlar: Wu, Haoquan, Ma, Hongming, Ye, Chunting, Ramirez, Danielle, Chen, Shuiping, Montoya, Jessica, Shankar, Premlata, Wang, Xiaozhong A., Manjunath, N.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235145/
https://ncbi.nlm.nih.gov/pubmed/22174840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028580
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