Improved siRNA/shRNA Functionality by Mismatched Duplex

siRNA (small interfering RNA) and shRNA (small hairpin RNA) are powerful and commonly used tools in biomedical research. Currently, siRNAs are generally designed as two 21 nt strands of RNA that include a 19 nt completely complementary part and a 2 nt overhang. However, since the si/shRNAs use the e...

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Bibliographic Details
Main Authors:	Wu, Haoquan, Ma, Hongming, Ye, Chunting, Ramirez, Danielle, Chen, Shuiping, Montoya, Jessica, Shankar, Premlata, Wang, Xiaozhong A., Manjunath, N.
Format:	Artigo
Language:	Inglês
Published:	Public Library of Science 2011
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3235145/ https://ncbi.nlm.nih.gov/pubmed/22174840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028580
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Improved siRNA/shRNA Functionality by Mismatched Duplex

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