Targeted Delivery of siRNA to Macrophages for Anti-inflammatory Treatment

Inflammation mediated by tumor necrosis factor-α (TNF-α) and the associated neuronal apoptosis characterizes a number of neurologic disorders. Macrophages and microglial cells are believed to be the major source of TNF-α in the central nervous system (CNS). Here, we show that suppression of TNF-α by...

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Detalhes bibliográficos
Main Authors: Kim, Sang-Soo, Ye, Chunting, Kumar, Priti, Chiu, Isaac, Subramanya, Sandesh, Wu, Haoquan, Shankar, Premlata, Manjunath, N
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890121/
https://ncbi.nlm.nih.gov/pubmed/20216529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.27
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