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shRNA and siRNA Delivery to the Brain
The limiting factor in in vivo RNA interference (RNAi) is delivery. Drug delivery methods that are effective in cell culture may not be practical in vivo for intravenous RNAi applications. Nucleic acid drugs are highly charged and do not cross cell membranes by free diffusion. Therefore, the in vivo...
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| 第一著者: | |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2007
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| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3572210/ https://ncbi.nlm.nih.gov/pubmed/17434235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addr.2007.03.008 |
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