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shRNA and siRNA Delivery to the Brain

The limiting factor in in vivo RNA interference (RNAi) is delivery. Drug delivery methods that are effective in cell culture may not be practical in vivo for intravenous RNAi applications. Nucleic acid drugs are highly charged and do not cross cell membranes by free diffusion. Therefore, the in vivo...

詳細記述

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書誌詳細
第一著者: Pardridge, William M.
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572210/
https://ncbi.nlm.nih.gov/pubmed/17434235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addr.2007.03.008
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