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shRNA and siRNA Delivery to the Brain
The limiting factor in in vivo RNA interference (RNAi) is delivery. Drug delivery methods that are effective in cell culture may not be practical in vivo for intravenous RNAi applications. Nucleic acid drugs are highly charged and do not cross cell membranes by free diffusion. Therefore, the in vivo...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3572210/ https://ncbi.nlm.nih.gov/pubmed/17434235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addr.2007.03.008 |
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