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RNAi mechanisms in Huntington’s disease therapy: siRNA versus shRNA
Huntington’s Disease (HD) is a genetically dominant trinucleotide repeat disorder resulting from CAG repeats within the Huntingtin (HTT) gene exceeding a normal range (> 36 CAGs). Symptoms of the disease manifest in middle age and include chorea, dystonia, and cognitive decline. Typical latency f...
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| Pubblicato in: | Transl Neurodegener |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5702971/ https://ncbi.nlm.nih.gov/pubmed/29209494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-017-0101-9 |
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