RNAi mechanisms in Huntington’s disease therapy: siRNA versus shRNA

Huntington’s Disease (HD) is a genetically dominant trinucleotide repeat disorder resulting from CAG repeats within the Huntingtin (HTT) gene exceeding a normal range (> 36 CAGs). Symptoms of the disease manifest in middle age and include chorea, dystonia, and cognitive decline. Typical latency f...

Full description

Saved in:
Bibliographic Details
Published in:Transl Neurodegener
Main Authors: Aguiar, Sebastian, van der Gaag, Bram, Cortese, Francesco Albert Bosco
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702971/
https://ncbi.nlm.nih.gov/pubmed/29209494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-017-0101-9
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items