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Strand antagonism in RNAi: an explanation of differences in potency between intracellularly expressed siRNA and shRNA
Strategies to regulate gene function frequently use small interfering RNAs (siRNAs) that can be made from their shRNA precursors via Dicer. However, when the duplex components of these siRNA effectors are expressed from their respective coding genes, the RNA interference (RNAi) activity is much redu...
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| Główni autorzy: | , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Oxford University Press
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3287203/ https://ncbi.nlm.nih.gov/pubmed/22039150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr927 |
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