Strand antagonism in RNAi: an explanation of differences in potency between intracellularly expressed siRNA and shRNA

Strategies to regulate gene function frequently use small interfering RNAs (siRNAs) that can be made from their shRNA precursors via Dicer. However, when the duplex components of these siRNA effectors are expressed from their respective coding genes, the RNA interference (RNAi) activity is much redu...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Jin, Xin, Sun, Tingting, Zhao, Chuanke, Zheng, Yongxiang, Zhang, Yufan, Cai, Weijing, He, Qiuchen, Taira, Kaz, Zhang, Lihe, Zhou, Demin
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
Matèries:
RNA
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287203/
https://ncbi.nlm.nih.gov/pubmed/22039150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr927
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars