Strand antagonism in RNAi: an explanation of differences in potency between intracellularly expressed siRNA and shRNA

Strategies to regulate gene function frequently use small interfering RNAs (siRNAs) that can be made from their shRNA precursors via Dicer. However, when the duplex components of these siRNA effectors are expressed from their respective coding genes, the RNA interference (RNAi) activity is much redu...

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Detalhes bibliográficos
Main Authors: Jin, Xin, Sun, Tingting, Zhao, Chuanke, Zheng, Yongxiang, Zhang, Yufan, Cai, Weijing, He, Qiuchen, Taira, Kaz, Zhang, Lihe, Zhou, Demin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287203/
https://ncbi.nlm.nih.gov/pubmed/22039150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr927
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