Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts

Dose-escalated radiation therapy for localized prostate cancer (PCa) has a clear therapeutic benefit; however, escalated doses may also increase injury to noncancerous tissues. Radiosensitizing agents can improve ionizing radiation (IR) potency, but without targeted delivery, these agents will also...

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Bibliografiske detaljer
Main Authors: Ni, Xiaohua, Zhang, Yonggang, Ribas, Judit, Chowdhury, Wasim H., Castanares, Mark, Zhang, Zhewei, Laiho, Marikki, DeWeese, Theodore L., Lupold, Shawn E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104752/
https://ncbi.nlm.nih.gov/pubmed/21555850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45109
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