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Silencing RORγt in Human CD4(+) T cells with CD30 aptamer-RORγt shRNA Chimera
Targeting specific T cell subtypes and intervening in their function are emerging a critical strategy for treatment of autoimmune diseases. Here we report that an RNA CD30 aptamer was utilized to deliver short hairpin RNA (shRNA) to CD30(+) T cells to target retinoic acid receptor-related orphan rec...
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| Veröffentlicht in: | Sci Rep |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6637186/ https://ncbi.nlm.nih.gov/pubmed/31316164 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46855-9 |
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